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This information provides guidance for treatment of bumblebee stings and allergies. Click here for clear instructions how to treat a bumblebee sting. In about 1% of the population, repeated stings (or in some cases only two or three stings) may lead to an allergic reaction, also called a general allergic reaction, a systemic allergic reaction, or an anaphylactic reaction. Because an allergic reaction involves antibodies formed during a previous exposure to an antigen, it is not possible to have an allergic reaction after the first sting. Allergic reactions usually become evident very soon after the sting (within half an hour).